Lesson 3.3.13.5
3.3.13.5 Action of anticancer drugs Quiz: AQA Chemistry, Unit 3
20 questions
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Lesson 3.3.13.5, Action of anticancer drugs: 20 multiple choice questions for the AQA Chemistry (7405), Unit 3: Organic chemistry, written with Revision Ninja.
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The 20 questions
-
What is the oxidation state of platinum in cisplatin?
- +1
- +4 (Pt(IV))
- +2 (Pt(II))
- 0
-
What type of reaction occurs when the anticancer drug cisplatin binds to DNA?
- Nucleophilic addition
- Electrophilic addition
- Free-radical substitution
- Ligand replacement
-
Which DNA base contains the nitrogen atom that forms a dative bond with platinum in cisplatin?
- Thymine
- Guanine
- Adenine
- Cytosine
-
Why does cisplatin binding to DNA stop cancer cells from replicating?
- Destroys phosphate backbone
- Inhibits ATP synthesis
- Breaks covalent bonds
- Prevents strand separation
-
What balance must society assess when evaluating the use of anticancer drugs like cisplatin?
- Cost and speed
- Yield and purity
- Benefits and side-effects
- Mass and volume
-
Which cells in the body are most damaged by the action of cisplatin?
- Rapidly dividing cells
- Non-dividing nerve cells
- Fully differentiated cells
- Slowly dividing cells
-
Which ligands in cisplatin are replaced during its reaction with DNA?
- Ammonia ligands
- Hydroxide ligands
- Water ligands
- Chloride ligands
-
What is the coordination number of platinum in cisplatin?
- 2
- 8
- 4
- 6
-
Which atom on guanine donates a lone pair of electrons to platinum in cisplatin?
- Oxygen atom
- Hydrogen atom
- Carbon atom
- Nitrogen atom
-
What type of chemical species is formed when ligands bond to a central platinum ion?
- Complex
- Free radical
- Carbocation
- Polymer
-
Why are cancer cells more vulnerable to treatment with cisplatin than most healthy cells?
- Slower division rate
- Faster division rate
- Lack of cytoplasm
- Higher membrane permeability
-
What must be balanced against therapeutic benefits when assessing the use of cisplatin?
- Storage temperature
- Adverse side effects
- Molecular mass
- Production costs
-
Which DNA base forms a coordinate bond with platinum in cisplatin?
- Cytosine
- Guanine
- Adenine
- Thymine
-
Which base in DNA does cisplatin bind to?
- Thymine
- Adenine
- Guanine
- Uracil
-
Which type of reaction occurs when cisplatin binds to guanine in DNA?
- Nucleophilic substitution
- Ligand replacement
- Free-radical substitution
- Electrophilic addition
-
Which healthy cells are most severely affected as a side effect of cisplatin?
- Bone matrix cells
- Hair follicle cells
- Muscle fibre cells
- Nerve cells
-
In the binding of cisplatin to DNA, what role is played by platinum?
- Electron pair acceptor
- Electron pair donor
- Proton acceptor
- Proton donor
-
Why must society assess the balance of using cisplatin in medical treatments?
- Short shelf life
- Insoluble in water
- High toxicity
- Low effectiveness
-
Which cellular process is directly prevented when cisplatin binds to DNA?
- DNA replication
- Glucose oxidation
- Protein translation
- ATP hydrolysis
-
What role do chloride ligands play during the reaction of cisplatin with DNA?
- Reducing agents
- Catalysts
- Electron donors
- Leaving groups
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